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The Role of Omega-3 in Arthritis Management

February 2025

Arthritis is a condition that affects millions of people worldwide, causing joint pain, stiffness, and inflammation. While medications and physical therapy are common treatments, diet also plays a crucial role in managing arthritis symptoms.

One of the most beneficial nutrients for arthritis management is omega-3 fatty acids—a type of healthy fat known for its powerful anti-inflammatory properties.

What Are Omega-3 Fatty Acids? 

Omega-3 fatty acids are essential fats that the body cannot produce on its own, meaning they must be obtained through diet or supplements.

There are three main types:

  • EPA (eicosapentaenoic acid) – Found mainly in fatty fish and fish oil.
  • DHA (docosahexaenoic acid) – Also found in fish, DHA is important for brain and joint health.
  • ALA (alpha-linolenic acid) – Found in plant-based sources like flaxseeds, chia seeds, and walnuts. The body can convert small amounts of ALA into EPA and DHA, but the process is not very efficient.

How Omega-3 Help with Arthritis?

Research has shown that omega-3 fatty acids can have several benefits for people with arthritis:

1. Reducing Inflammation: 

One of the primary benefits of omega-3s is their ability to reduce inflammation. Arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA) is characterised by chronic inflammation in the joints. Omega-3s help by:

  • Decreasing the production of inflammatory chemicals like cytokines and prostaglandins.
  • Lowering levels C-reactive protein (CRP), a marker of inflammation in the blood.
  • Altering the immune system to reduce autoimmune responses in conditions like RA.


2. Easing Joint Pain and Stiffness:

Multiple studies have found that people with arthritis who consume omega-3s experience less joint pain and morning stiffness. Omega-3s may help by lubricating the joints and improving mobility, making daily activities easier and more comfortable.

For RA, a 2021 review of 70 studies on fish oil and other dietary supplements found that fish oil significantly improved disease activity, pain, and morning stiffness in people with rheumatoid arthritis (RA). Those who took fish oil supplements responded more effectively to disease-modifying antirheumatic drugs (DMARDs) and reached remission faster. Higher doses (greater than 2.6 grams a day of fish oils) decreased inflammatory biomarkers (1).

Regarding lupus, most studies have shown that fish oil provides benefits, including reduced disease activity and lower levels of inflammatory markers (1).


3. Supporting Cartilage Health:

For people with osteoarthritis, omega-3s may help slow down cartilage degradation and improve joint function. Some research suggests that omega-3s reduce the enzymes that break down cartilage, potentially delaying arthritis progression.

Researchers believe that the anti-inflammatory effects of omega-3 fatty acids may help reduce the mild, ongoing inflammation linked to osteoarthritis (OA). This could potentially slow down cartilage breakdown and the progression of OA, but more research is needed. If inflammation and cartilage damage decrease, it may lead to better joint function and relief from common OA symptoms like pain and stiffness (3).

Best Food Sources of Omega-3s

Including omega-3-rich foods in your diet is an effective way to manage arthritis symptoms. Here are some of the best sources:

Fatty Fish (Highest in EPA & DHA) 

  • Salmon
  • Mackerel
  • Sardines
  • Herring
  • Trout
  • Tuna

How to Add It to Your Diet:

  • Eat grilled or baked fish twice a week.
  • Add canned sardines or tuna to salads.
  • Make salmon patties or fish tacos for a tasty meal.


Plant-Based Sources (ALA Omega-3s)

  • Chia seeds
  • Flaxseeds
  • Walnuts
  • Hemp seeds
  • Edamame
  • Algal oil (derived from algae, a great option for vegetarians)

How to Add It to Your Diet:

  • Sprinkle flaxseeds or chia seeds into smoothies or oatmeal.
  • Snack on a handful of walnuts.
  • Use flaxseed oil or walnut oil in salad dressings.


Omega-3 Supplements: Are They Necessary?

For those who do not eat fish regularly, omega-3 supplements (such as fish oil or algae-based omega-3s) can be a good option. When choosing a supplement, consider the following:

  • Look for high-quality fish oil with a combination of EPA and DHA.
  • Choose supplements that are certified for purity to avoid contaminants like mercury.
  • If you are vegetarian or vegan, algae-based omega-3 supplements are a great alternative.

But speak with your GP or pharmacist for more information on recommendations and dosages.

Precautions and Considerations

While omega-3s offer many benefits, it’s important to use them wisely:

  • Blood Thinning Effect: Omega-3s can act as a mild blood thinner. If you take blood-thinning medications, consult your doctor before taking high doses.
  • Digestive Issues: Some people experience mild side effects like bloating or fishy burps when taking fish oil. Choosing enteric-coated capsules or taking supplements with meals may help.
  • Balance with Omega-6 Intake: Omega-6 fatty acids (found in processed foods and vegetable oils) can promote inflammation when consumed in excess. Aim for a healthy balance of omega-3 to omega-6 in your diet.


Here Are 5 Quick and Nutritious Omega-3 Rich Recipes:

1. Grilled Salmon with Lemon & Garlic:

  • Marinate salmon fillets with olive oil, garlic, and lemon juice.
  • Grill for 5–7 minutes per side.
  • Serve with roasted vegetables or a quinoa salad.


2. Chia Seed Pudding:

  • Mix 2 tbsp chia seeds with 1 cup almond milk.
  • Add honey and vanilla extract.
  • Let sit overnight in the fridge.
  • Top with fresh berries and walnuts before serving.


3. Walnut & Flaxseed Smoothie:

  • Blend 1 banana, 1 tbsp ground flaxseeds, ¼ cup walnuts, 1 cup almond milk, and a handful of spinach.
  • Add cinnamon or honey for extra flavour.


4. Tuna & Avocado Salad:

  • Mix canned tuna with diced avocado, lemon juice, and olive oil.
  • Serve over whole-grain toast or mixed greens.


5. Omega-3 Energy Bites:

  • Combine ½ cup flaxseeds, ½ cup chia seeds, ½ cup walnuts, ¼ cup almond butter, and honey.
  • Roll into small balls and refrigerate for a quick snack.


Incorporating omega-3 fatty acids into your arthritis management plan can provide significant benefits, from reducing inflammation to improving joint mobility and easing pain. Whether through fatty fish, plant-based sources, or supplements, adding omega-3s to your routine is a natural and effective way to support joint health.

While omega-3s won’t cure arthritis, they can be a valuable part of a holistic approach that includes a healthy diet, regular exercise, stress management, and proper medical care.

How The Arthritis Movement can help



Sources

  • Omega-3 Fatty Acids for your health. Arthritis Foundation, Dec 8 2022. [cited Feb 6, 2025]. Available from: https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/omega-3-fatty-acids-for-health
  • Kostoglou-Athanassiou I, Athanassiou L, Athanassiou P. The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis. Mediterr J Rheumatol. 2020 Jun 30;31(2):190-194. doi: 10.31138/mjr.31.2.190. PMID: 32676556; PMCID: PMC7362115.
  • Cordingley DM, Cornish SM. Omega-3 Fatty Acids for the Management of Osteoarthritis: A Narrative Review. Nutrients. 2022 Aug 16;14(16):3362. doi: 10.3390/nu14163362. PMID: 36014868; PMCID: PMC9413343.

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